雷蓓蕾

   　基本信息：

　　雷蓓蕾，女，1984年生，博士，副教授，硕士研究生导师。

　　2006年本科毕业于兰州大学化学化工学院；2011年6月博士毕业于兰州大学化学化工学院；2009年9月至2011年4月在美国肯塔基大学药学院联合培养。2011年7月进入伟德BETVLCTOR1946工作。中国化学会会员。

　　开设课程：

　　承担本科生《生物信息学》、《生物信息学综合实验》，参与研究生《生物信息学研究进展》课程教学工作。

　　

　　研究方向：

　　植物激素类似物的计算机辅助分子设计；

　　化学小分子对植物生长及逆境响应的调控。

　　

　　主持的科研项目：

　　国家自然科学基金青年基金，基于靶标BRI1的新型油菜素内酯受体激动剂的合理设计（21302153，2014-2016）；

　　陕西省自然科学基金青年项目，油菜素甾醇类植物激素类似物的虚拟筛选研究及生物活性评价（2017JQ3003，2017-2018）；

　　中央高校基本科研业务费青年培育项目，基于药效团的BRI1激动剂的虚拟筛选及活性评价（2015）；

　　发表论文：

　　Lei, B. L., Heng, NJ, Dang, XX, Liu, J. Y., Yao, X. J and Zhang CL*. Structure based in silico identification of potentially non-steroidal brassinosteroids mimics. Molecular Biosystems, 2017. 13(7): p.1364-1369.

　　Lei, B. L.*, Liu, J. Y., and Yao, X. J. Unveiling the molecular mechanism of brassinosteroids: Insights from structure-based molecular modeling studies . Steroids, 2015. 104: p. 111-117.

　　Lei, B. L.*, Li, J. Z., and Yao, X. J., A Novel Strategy of Structural Similarity Based Consensus Modeling. Molecular Informatics, 2013. 32(7): p. 599-608.

　　Lei, B. L., Adel, H. and Zhan, C.-G.*, Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations. Theoretical Chemistry Accounts, 2012. 131(4): p. 1203-1213.

　　Wei, D. H., Lei, B. L., Tang M. S., and Zhan C.-G.*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin , Journal of the American Chemical Society, 2012. 134(25): p. 10436-10450.

　　Lei, B. L., Hameed, Mdma, Hamza, A., Wehenkel, M., Muzyka, J. L., Yao, X. J., Kim, K. B., and Zhan, C. G.*, Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations. Journal of Physical Chemistry B, 2010. 114(38): p. 12333-12339.

　　Lei, B. L., Ma, Y. M., Li, J. Z., Liu, H. X., Yao, X. J.*, and Gramatica, P., Prediction of the adsorption capability onto activated carbon of a large data set of chemicals by local lazy regression method. Atmospheric Environment, 2010. 44(25): p. 2954-2960.

　　Lei, B. L., Li, J. Z., Lu, J., Du, J., Liu, H. X., and Yao, X. J.*, Rational Prediction of the Herbicidal Activities of Novel Protoporphyrinogen Oxidase Inhibitors by Quantitative Structure-Activity Relationship Model Based on Docking-Guided Active Conformation. Journal of Agricultural and Food Chemistry, 2009. 57(20): p. 9593-9598.

　　Lei, B. L., Li, S. Y., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2009. 1216(20): p. 4434-4439.

　　Lei, B. L., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4. Analytica Chimica Acta, 2009. 644(1-2): p. 17-24.

　　Lei, B. L., Du, J., Li, S. Y., Liu, H. X., Ren, Y. Y., and Yao, X. J.*, Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors. Journal of Computer-Aided Molecular Design, 2008. 22(10): p. 711-725.

　　Lei, B. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Accurate prediction of aquatic toxicity of aromatic compounds based on Genetic Algorithm and Least Squares Support Vector Machines. Qsar & Combinatorial Science, 2008. 27(7): p. 850-865.

　　联系方式:

　　通讯地址：陕西杨凌，伟德BETVLCTOR1946

　　邮政编码：712100

　　E-mail: leibl@nwsuaf.edu.cn